6) Which of the following compounds is not a cofactor required for β -oxidation? C.FAD D.CoA E.NADP

β oxidation refers to the oxidative decomposition of fatty acid β oxidase system after fatty acid coenzyme A enters mitochondrial matrix. Because oxidation occurs on the β -carbon atom of fatty acid acyl group, it is called β-oxidation.

NAD, FAD and CoA are needed as reactants in β -oxidation process; In addition, the enzyme that catalyzes the β -oxidation of fatty acids is in the mitochondrial matrix, but the long-chain acyl-CoA can not pass through the mitochondrial inner membrane freely, and it needs carrier transport to enter the mitochondrial matrix. This carrier is carnitine.

Taking stearic acid as an example, the total reaction of β -oxidation is as follows:

CH3(CH2) 14 cos coa+7 nad+7 fad+hs coa+7H2O→8 ch 3 cos coa+7 fadh 2+7 NADH+7H

The whole process does not need NADP.