? Brief introduction of sinomenine

Sinomenine, also known as sinomenine and sinomenine, is sinomenine, sinomenine or sinomenine stem. Every summer and autumn, the vines are cut and dried for medicine. Its nature is flat, its taste is bitter and pungent, and it enters the liver and spleen meridians. It contains alkaloids such as sinomenine, magnoliaine, tetrandrine, tetrahydroepiberberine, sinomenine, potato lanine, methyl palmitate, dictamnine, stephanine, etc. It also contains β -sitosterol and stigmasterol. Has the effects of expelling pathogenic wind, removing dampness, dredging collaterals and promoting diuresis, and can be used for treating rheumatism, arthralgia, paralysis and itching. "Compendium of Materia Medica" contains "Treating rheumatism, knee pain, paralysis, itching, injury, sores and swelling, using medicinal liquor". "Records of Medicinal Plants in Tianmu Mountain, Zhejiang Province" also records: "diuresis, diarrhea, and blood dampness. It can be used for treating rheumatic edema, beriberi, rheumatic joint pain, mouth-eye deviation, carbuncle swelling and malignant sores. 」

Modern pharmacological research shows that sinomenine contained in sinomenine has definite analgesic effect. When it is used with propylene morphine, it has no antagonistic effect, but has synergistic effect. The dosage of analgesia is about 10 times that of morphine, and the duration is short. Continuous use can also produce tolerance, but it is slower than morphine and there is no cross tolerance with morphine. Combined with ipratropium, the effect is enhanced; Sinomenine has a definite acute hypotensive effect, which is rapid, significant and lasting whether it is made into intravenous injection or oral administration, but it has rapid tolerance after repeated administration. Injection of sinomenine can increase the secretion and acidity of gastric juice and stimulate gastrointestinal tract; Sinomenine has obvious anti-inflammatory effect on arthritis, and also has inhibitory effect on trichomonas and plasmodium.

Clinically, it is often combined with Angelica sinensis and Lycium barbarum to treat wind-cold-dampness arthralgia. It can also be used as a single medicine. It can be decocted into ointment for oral administration and can also be fumigated and washed for external use, with good effects of relaxing muscles and tendons, promoting blood circulation, diminishing inflammation and relieving pain.

Common prescription: Rheumatalgia: 90g sinomenine, 30g tetrandra root, 500ml wine, boiled and drunk; Treatment of rheumatoid arthritis: Caulis Sinomenii and Caulis Sargentodoxae each 15g, decocted in water, and taken with appropriate amount of wine; Treatment of joint pain: take 60 grams of sinomenine, decoct it in water, and wash away the pain.