Which drugs for treating gout are truly effective?

Colchicine should be the first choice for acute gout. This drug has selective anti-inflammatory and analgesic effects on acute gouty arthritis. Although phenylbutazone and indomethacin do not have the above-mentioned effects, they also have a good symptom relief effect on gouty arthritis and can be selected. Allopurinol can reduce the biosynthesis of uric acid; probenecid and benzotrione can promote uric acid excretion and are generally used in patients with chronic gout. Gout is a metabolic disease. In addition to the above-mentioned drug treatment, you must also pay attention to adjusting your diet, that is, not eating high-purine foods, such as heart, liver, kidney, brain, sardines, yeast, etc., strictly abstain from alcohol, drink more water, and increase daily urine output. It is better to have more than 2000 ml. It is strictly prohibited to use drugs that inhibit uric acid excretion, such as salicylic acid, acetylpyrazine, thiazide diuretics, furosemide, diuretic acid, etc. 1. Colchicine: Colchicine is an alkaloid extracted from the bulbs and seeds of Colchicum. It can inhibit the increase in white blood cells caused by urate crystals and interfere with the chemotaxis of white blood cells, so it has anti-inflammatory and analgesic effects. 2. Nonsteroidal anti-inflammatory drugs: Nonsteroidal anti-inflammatory drugs have the same effect as colchicine in the treatment of gouty arthritis. However, due to the serious side effects of colchicine, many gout patients prefer to use nonsteroidal anti-inflammatory drugs for treatment. Nonsteroidal anti-inflammatory drugs can relieve inflammatory symptoms such as redness, swelling, heat, and pain in joints, improve the function of certain muscles, bones, and joints, and can effectively prevent edema. The non-steroidal anti-inflammatory drugs commonly used in clinical practice currently include indomethacin, diclofenac, ibuprofen and rofecoxib. 3. Glucocorticoid drugs: Glucocorticoid drugs can inhibit non-infectious inflammation, reduce joint congestion and edema, and have the characteristics of rapid onset of action. However, because gout patients are very likely to have symptoms relapse after they stop using glucocorticoid drugs, this type of drug is only suitable for individual gout patients whose symptoms are very severe and recurring or who are ineffective after the above-mentioned drug treatments. Currently, the commonly used glucocorticoid drugs in clinical practice include prednisone, hydrocortisone, and prednisolone. 4. Uric acid drugs: Uric acid drugs mainly include salicylic acid drugs, probenecid, sulfinpyrazone, benzbromarone, etc. This type of drug can prevent the reabsorption of uric acid by the renal tubules and increase the excretion of uric acid, thereby reducing the blood uric acid level in the human body.