What is the genetic explanation of the heterochromatic pupil hole in cats?

"Yuanyang eye" is the expression of iris heterochromia, which may be caused by congenital inheritance and acquired variation. ? Congenital factors are mainly related to heredity. Because the iris color of eyes is influenced by genetic factors, if one parent has blue eyes and the other parent has gray eyes, then the offspring may have 1 blue eyes or 1 gray eyes, but it is also possible that 1 iris of eyes is blue and the other pair 1 is gray, which may be related to Waardenburg syndmme (WADENBERG). Waldenberg syndrome is short for Waldenberg syndrome. Also known as inner canthus cleft deafness syndrome or deafness and white-haired eye disease syndrome, its etiology is related to chromosome 2 aberration. PAX3, a transcription factor located on chromosome 2, is mutated, resulting in the abnormal expression of the gene. 195 1 year, Dutch ophthalmologist and geneticist Waldenberg first proposed a new syndrome in the literature. Patients usually have blue eyes, which have no effect on vision, but may have hearing impairment and suffer from Hirschsprung's disease. This is also the reason why mandarin duck-eyed cats 1 are often deaf. Single deafness is not a big problem for pet cats, but if mandarin ducks live in the wild, they will encounter many difficulties because of single deafness.

The acquired cause may be iris hairy inflammation caused by immune complex, which leads to iris injury and atrophy. It may also be caused by the loss of iris pigment, which may be related to gene mutation. ? There is also a cat with Yuanyang eyes, also called "Yin and Yang eyes". The same eye will show different colors. For example, the milk tea of a star cat in Taiwan Province Province has yellow and blue eyes at the same time, which is a genetic mutation after hybridization, which is even rarer. In fact, not only cats, but also the characteristics of Yuanyang eyes can even appear in dogs and humans!