Introduction to Voltaren

Contents 1 Pinyin 2 English reference 3 Instructions for diclofenac 3.1 Drug name 3.2 English name 3.3 Alias ​​of Voltaren 3.4 Classification 3.5 Dosage form 3.6 Pharmacological effects of diclofenac 3.7 Pharmacokinetics of diclofenac 3.8 Indications of diclofenac 3.9 Diclofenac Contraindications 3.10 Precautions 3.11 Adverse reactions of diclofenac 3.12 Usage and dosage of diclofenac 3.13 Interactions between Voltaren and other drugs 3.14 Expert comments This is a redirected entry, sharing the content of diclofenac. For the convenience of reading, diclofenac in the following text has been automatically replaced by voltaren. You can click here to restore the original appearance, or use the note method to display 1 Pinyin

fú tā lín 2 English reference

voltaren 3 Voltaren Instructions 3.1 Drug name

Voltaren 3.2 English name

Diclofenac, Diclofenac Sodium, Cataflam, Dichronic, Kriplex, VOLTAREN 3.3 Alias ​​of Voltaren

Diclofenac sodium acetate ;Jiaxi;Diclofenac;Amirel;Orphen;Docofena;Diclofenac;Dihydrofenate sodium;Feiyan;Petalin;Jiabei;Diclofenac sodium;Diclofenac Sodium acid; Ying Taiqing; Voltaren sodium; Futalin; Difenac; Diclofenac; Kefulan; Norfodin; Tianxinlide; Ying Taiqing capsule; Blesin; Diclofe; Diclofenac Sodium

3.4 Classification

Nervous system drugs gt; Antipyretics and analgesics gt; Other 3.5 Dosage Forms

1. Tablets 25mg, 50mg, 75mg;

2. Relief Release capsule: 100mg;

3. Injection: 75mg;

4. Ointment: 10mg;

5. Latex: 1%, 10mg;

6. Suppositories: 25mg, 50mg, 100mg.

7. Eye drops: 0.1. 3.6 Pharmacological effects of Voltaren

The mechanism of action of Voltaren is to selectively cut off the action link of cyclooxygenase in the arachidonic acid metabolism series and block the synthesis pathway of prostaglandin E2 (PGE2). Inhibit its mutagenic and pain-causing effects. Voltaren is a phenylacetic acid anti-inflammatory analgesic with significant anti-rheumatic, anti-inflammatory, analgesic and antipyretic effects. Its effect is 2 to 2.5 times stronger than indomethacin and 26 to 50 times stronger than aspirin. It is characterized by strong efficacy, mild adverse reactions, small dosage and small individual differences. Voltaren has significant antirheumatic, analgesic, anti-inflammatory and antipyretic effects. It can effectively relieve joint pain and improve their activities, and is well tolerated. Voltaren tablets have a hypoallergenic coating that prevents the active substances in the tablets from being released after leaving the stomach. Therefore, they can be used in patients with sensitive stomachs. Voltaren is taken orally at 75 to 150 mg per day. Its analgesic and anti-inflammatory effects on rheumatoid arthritis, osteoarthritis, and adhesive spondylitis are similar to those of aspirin, ibuprofen, indomethacin, ketoprofen, and naproxen. Many studies have proven that Voltaren has a strong inhibitory effect on the collapse of the blood atrial water barrier caused by mechanical, chemical, biological and other factors. In recent years, studies have found that Voltaren can reduce the perception and sensitivity of the cornea and exhibit a corneal analgesic effect. Its detailed mechanism is still unclear.

3.7 Pharmacokinetics of Voltaren

Voltaren can be rapidly absorbed when administered as Voltaren oral solution, rectal suppository, or via intramuscular injection. When enteric-coated tablets are used, absorption tends to be slower, especially when taken with food. Although Voltaren is absorbed rapidly and completely after oral administration, with the peak blood dose reaching the peak within 2 hours, its first-pass metabolism is significant, and only 50% of the drug enters the systemic circulation. Voltaren is also absorbed through the skin. At therapeutic concentrations, the protein binding rate is higher than 99. It can penetrate into the synovial fluid and can be retained until the blood concentration drops. It can be distributed into breast milk, but the amount is very low and will not cause harm to the breastfed baby. The final plasma t1/2 is about 1 to 2 hours. The main metabolite is oxyvoltaline, and the metabolites glucuronic acid and sulfuric acid are combined and excreted in the urine and bile. Healthy subjects took Voltaren 100mg orally, Cmax4485ng/ml, tmax1.2h, t1/21.33h, Ke0.56 per hour. Intramuscular injection of 75mg, Cmax2.73μg/ml, tmax25.3min. Voltaren topical eye drops have good intraocular permeability, and the drug retention time in the aqueous humor is longer, which is about three times that of flurbiprofen. The reason may be that the cornea has a certain accumulation effect on diclofenac. 3.8 Indications of Voltaren

It is clinically used for rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, and osteoarthrosis. It is suitable for all kinds of moderate pain, such as post-operative and post-traumatic pain, and acute muscle pain. Bone diseases; and fever caused by various inflammations, etc. Also used for acute gout and cancer, soft tissue injuries, and post-operative pain. Used to prevent intraoperative miosis and treat postoperative inflammation during cataract extraction. Anti-infectious treatment of non-infectious inflammation in ophthalmology, including non-infectious inflammation caused by surgical and non-surgical factors, such as uveitis, keratitis, scleritis, and episcleritis; inhibiting corneal neovascularization; inhibiting inflammation during cataract surgery It can prevent miotic reaction; prevent postoperative inflammatory reaction and the formation of cystoid macular edema, and promote the formation of filtering blebs after glaucoma filtering surgery; it also has a therapeutic effect on allergic conjunctivitis. 3.9 Contraindications of Voltaren

1. Those with active peptic ulcers, or those who have experienced severe gastrointestinal lesions such as ulcers, bleeding, and perforation caused by previous use of Voltaren;

2. Due to water Asthma attacks, urticaria and allergic rhinitis induced by cylic acid or other prostaglandin synthase inhibitors.

3. It is prohibited for those allergic to Voltaren or other non-steroidal anti-inflammatory drugs (NSAIDs). 3.10 Precautions

1. (1) Asthma; (2) Cardiac insufficiency and hypertension. It may cause water retention and edema after taking the medicine; (3) Hemophilia or other bleeding diseases (including coagulation disorders and abnormal platelet function). Because the bleeding time is prolonged after taking the medicine, the bleeding tendency is aggravated; (4) History of peptic tract ulcer. Gastrointestinal adverse reactions are prone to occur after taking the drug, including the formation of new ulcers; (5) History of rash; (6) Urticaria; (7) Hepatic porphyria; (8) Loss of extracellular fluid; (9) Breastfeeding women ; (10) Renal insufficiency;

2. Due to the increase in renal adverse reactions after medication, which may even lead to renal failure, especially in the elderly, routine follow-up should be performed to check liver and kidney function during medication.

3. Those who have potential damage to liver and kidney function and chronic drinkers should also pay close attention to changes in liver and kidney function when taking Voltaren.

4. When taking Voltaren for a long time, liver and kidney function and blood counts should be monitored as a preventive measure.

5. Voltaren is not suitable for people with simple fever.

6. It is best to take Voltaren before meals. 50m sanitizer is not suitable for use by children.

7. Voltaren and miotic agents should not be used at the same time. Glaucoma patients should stop using miotic agents 3 hours before surgery. 3.11 Adverse reactions of Voltaren

1. Gastrointestinal discomfort (such as upper abdominal pain, nausea, vomiting, diarrhea, etc.), headache, dizziness, dizziness, skin erythema or rash.

2. Rare: gastrointestinal bleeding, peptic ulcer, lethargy, abnormal liver function (including jaundice hepatitis), edema, allergic reactions (such as urticaria, rash, bronchospasm, etc.) or anaphylactoid Such reactions include hypotension.

3. Individual cases: sensory or visual impairment (blurred vision, diplopia), tinnitus, insomnia, irritability, convulsions; herpes, eczema, erythema multiforme, Lyell syndrome, alopecia, photosensitivity reaction, etc. ; Acute renal insufficiency, urinary abnormalities (such as hematuria), interstitial nephritis, nephrotic syndrome; thrombocytopenia, leukopenia, agranulocytosis, hemolytic anemia, aplastic anemia; fulminant hepatitis.

4. After local use, there may be an instant mild stinging and burning sensation. No treatment is required and it will disappear on its own after 1 minute. 3.12 Usage and dosage of Voltaren

1. Take 25 mg each time, 3 times a day, and take the whole tablet with water.

2. Suppository *** Insertion: 50mg each time, 2 times a day.

3. Intramuscular injection: 75 mg each time, once a day, deep into the gluteal muscle, and again after a few hours if necessary.

4. Children, 1~3mg/kg per day. Swallow tablet whole.

5. Ophthalmic medication: (1) To prevent miosis during cataract removal, drop eye drops 4 times within 2 hours before surgery, 1 drop each time; (2) To treat inflammation after cataract removal, 24 hours after surgery Start eye drops, 1 drop each time, 4 times a day, for 10 to 14 days. (3) Before eye surgery: Generally 4 times before surgery (3 hours before, 2 hours before, 1 hour before, 30 minutes before); (4) After eye surgery: 1 to 4 times a day, 1 drop each time; (5) Other non-surgical treatments For anti-inflammatory use: 1 drop each time, 4 to 6 times a day. 3.13 Drug interactions

1. When Voltaren is combined with lithium salts or digoxin, the plasma concentrations of the latter two may increase.

2. Adverse reactions may increase when combined with systemic nonsteroidal anti-inflammatory drugs or glucocorticoids.

3. Combined use with aspirin can reduce the blood concentration of Voltaren.

4. When used in combination with potassium-sparing diuretics, serum potassium levels may increase and should be monitored carefully.

5. When used in combination with oral anticoagulants, relevant laboratory tests should be performed to ensure efficacy and medication safety.

6. When taking Voltaren within 24 hours before and after taking methotrexate, careful observation should be made. The plasma concentration of methotrexate may be increased and the toxicity may also be enhanced. 3.14 Expert comments