What do you think of the golden body and the town?
Parkinson's syndrome is caused by the degeneration of neurons in the brain. It usually occurs over the age of 40, and can be static for months or years, but it is often progressive.
Parkinson's disease is characterized by a series of signs of nervous system involvement, the most important of which is:
(1) bradykinesia;
(2) Stiffness-a sense of heaviness and stiffness in limbs;
(3) Hands tremble at rest, sometimes feet tremble;
(4) Abnormal posture-the patient's neck and trunk are bent, and his arms can't swing freely when walking.
Parkinson's disease rarely shortens life expectancy.
Late tremor, bradykinesia and rigidity can affect limbs and trunk; The language is vague, the patient's limbs and trunk bend forward, his steps are short and staggered, and he is easy to fall.
People of all classes and races in the world may suffer from Parkinson's disease.
Principles of treatment of Parkinson's syndrome
Parkinson's syndrome is caused by a lack of dopamine, a chemical transmitter in the brain. So people try their best to supply dopamine. However, limited by the blood-brain barrier, it is difficult to really reach the brain, and the substantive therapeutic purpose cannot be achieved at all.
The deep gray matter part of the brain (called basal ganglia, especially substantia nigra) in patients with Parkinson's disease is diseased or degenerated. The substantia nigra is connected with the striatum (caudate nucleus and globus pallidus) and contains melanocytes. Normal people produce a variety of chemical transmitters, the most important of which is dopamine.
Dopamine levels in substantia nigra of the brain decrease with age. If it is reduced to the normal level of 1/5, symptoms and signs of Parkinson's disease will appear. Under normal circumstances, there is a balance between dopamine and another neurotransmitter called acetylcholine in the brain.
Acetylcholine exists in many areas of the brain, and its function is to preserve normal memories. Dopamine is exhausted, resulting in a relative excess of acetylcholine.
There are mainly two kinds of drugs used to treat Parkinson's disease: one is dopamine, that is, levodopa and its product madopa and [Sinemet[ compound carbidopa tablet (carbidopa-levodopa tablet)]. The other is drugs that can reduce acetylcholine and restore the balance between them, that is, anticholinergic drugs, such as Antan, DeSzipal, Co-gentin, etc.
As for the use of anticholinergic drugs, that is, drugs that reduce acetylcholine, to restore the balance between the two, this is a very clever treatment, which is tantamount to killing the goose that lays the golden egg.
Under normal circumstances, our brain should secrete dopamine, a hormone, to restore dopamine secretion function in caudate nucleus and globus pallidus. Among them, rhythmic electrical stimulation is recognized as an effective treatment. Using electro-acupuncture to stimulate globus pallidus to treat this disease, there are precedents at home and abroad, and good results have been achieved, but it can only be done in large hospitals, and one operation is equivalent to a minor operation, which is quite expensive to do repeatedly.
It can be seen that the treatment principle of Parkinson's syndrome should be to activate brain cells and promote the recovery of dopamine secretion function in caudate nucleus and globus pallidus.