I heard that alprostadil dry emulsion (Udil) is now distributed free of charge at the entrance to the Shanghai World Expo? Have you been there? Is there any charge?
Youdier?
——Alprostadil Dried Emulsion for Injection
Alprostadil Dried Emulsion for Injection
Chongqing Yaoyou Pharmaceutical Co., Ltd., as a leading pharmaceutical company in Chongqing, has been fighting on the front line of human health for many years. From 2007 to 2009, the company achieved high growth for three consecutive years. In 2010, the company is expected to achieve annual sales revenue exceeding 1 billion yuan. Since then, Chongqing Yaoyou Pharmaceutical Co., Ltd. has gradually achieved sales revenue exceeding 3 billion by 2013 and reaching 10 billion by 2018 through the simultaneous development of three business models, becoming the leader in freeze-dried preparations. , the leader in sustained and controlled release preparations, a great strategic goal of China's best pharmaceutical preparation company.
Therefore, Chongqing Yaoyou Pharmaceutical invests 5%-10% of its annual sales in the research and development of new drugs every year.
Alprostadil is an internationally recognized new generation of broad-spectrum endogenous drug that has a wide range of strong pharmacological activities on cell tissues. However, alprostadil has poor water solubility, easily produces degradable impurities when heated, and is highly irritating to blood vessels. In view of the above characteristics of alprostadil, Chongqing Yaoyou Pharmaceutical Co., Ltd. invested millions and spent 7 years to successfully develop the third generation alprostadil preparation - alprostadil dry emulsion for injection. This product uses lipid microspheres as carriers and uses special freeze-drying protective agents to prepare efficient and stable targeted drug preparations.
Since the first generation of alprostadil for injection entered the market, its pharmacological effects have been unanimously recognized by experts from all walks of life. At present, the annual sales of alprostadil preparations on the market reach 2 billion, and show a continuous growth trend. Among them, "Kaishi", which dominates the market, has annual sales of more than 1 billion. It can be seen that the market potential of alprostadil preparations is very huge. The successful launch of the third generation alprostadil preparation of Chongqing Yaoyou Pharmaceutical Co., Ltd. - alprostadil dry emulsion for injection will definitely bring greater sales. increase.
As early as 2004, our company's new dosage form of the third generation alprostadil preparation passed the approval of the National Pharmacopoeia Commission and was officially defined as "alprostadil dry emulsion for injection".
The research and development of the third-generation alprostadil preparation has gone through many twists and turns, and with each twist and turn, its birth is one step closer to us. In this R&D team, the top team has dedicated experts from Europe and North America to provide on-site or remote technical support, including:
Senior nanoliposome drug development process control expert, Anthony Boey
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Senior nanoliposome drug development freeze-drying technology expert, Gaston Griesbeck
Senior nanoliposome drug development quality control, analysis and testing expert, Cidy Ouyang
Senior nanoliposome drug development pilot industry preparation expert, Clay Flowers
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At the same time, we are actively looking for R&D partners to provide technical support, and successively in 2005 Chongqing Kemei Yaoyou Nanotechnology Development Co., Ltd. was jointly established with Kemei Nano Biotechnology Co., Ltd. of the United States, and jointly established a laser particle analysis technology application laboratory in western China with Malvern Company of the United Kingdom, a world-renowned expert in nanometer measurement equipment. , enabling this key nano-research technology to be more widely promoted and applied in China.
The third-generation alprostadil preparation, Youdier, is rich in two core technologies: "lipid microsphere carrier technology" and "lipid microsphere protection technology". "Lipid microsphere carrier technology" has the characteristics of good targeting, sustainability, high efficiency, and low side effects:
Targeting - lipid microsphere carriers accumulate at the lesion site with their unique affinity ;
Sustainability - under the protective effect of lipid microspheres, the inactivation of alprostadil mainly in the lungs is significantly reduced;
High efficiency - only a few doses of traditional dosage forms are needed One-tenth of the dosage, with better efficacy;
Low side effects - under the barrier effect of lipid microspheres, alprostadil's irritation and inflammatory response to blood vessels is significantly reduced;
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The introduction of "lipid microsphere protection technology" makes Udil's dosage form more stable and safer to use:
The dosage form is more stable - Udil only needs to be Store in a cool place (not exceeding 20°C). The advantage of this is that there is no need for refrigerated storage in the south, and in the north there is no need to worry about the medicine freezing due to low temperature, thus affecting clinical use. (Beichang, Kaishi and other similar products must ensure that the ambient temperature range is 0-5℃ during transportation and storage)
It is safer to use medicine - there are already products on the market produced by Beijing Tide Pharmaceutical Co., Ltd. "Alprostadil Injection", trade name "Kaishi", is also a type of preparation using lipid microspheroidization technology. However, due to the shortcomings of its own production process, the main impurity of this variety, PGA1, is quite high. The quality standard stipulates that the limit is as high as 60%, and other impurities in the product are not controlled.
After nearly 10 years of exploration, Yaoyou Company has prepared "alprostadil dry emulsion for injection" through sterile filtration and low-temperature freeze-drying technology, which can strictly control the impurity PGA1 within 10% and other impurities within 1%. Within %, it shows that the freeze-drying method adopted by Yaoyou Company is more conducive to product quality control. Therefore, Yaoyou Company's alprostadil dry emulsion for injection has put forward stricter quality standards than "Kaishi" to effectively ensure product quality. Due to the improvement in the quality of this product, this product can be stored in common cool conditions, instead of the rather stringent storage conditions required by "Kaishi". Through a large amount of scientific research, Yaoyou's technical staff have explored special freeze-drying protective agents and strict freeze-drying process control to realize the freeze-drying technology of lipid microspheres, so that this product not only retains the physical properties of lipid microspheres, but also significantly Improved the chemical stability of lipid microspheres. Therefore, the implementation standard of "Youdier" is only one-sixth of the implementation standard of alprostadil injection.
Such core technologies have brought greater market competitiveness to Youdil. Its successful launch will definitely have a huge impact on the current alprostadil drug market, and drug lovers will also With this blockbuster product, we will take a big step towards our dream of tens of billions.