The efficacy and role of traditional Chinese medicine for windproof: The efficacy and role of traditional Chinese medicine for windproof
The Chinese medicine Fangfeng is the name of a tribal chief in ancient legends; it is also the name of a medicinal herb, mainly produced in Heilongjiang, Sichuan, Inner Mongolia and other places, and used raw. What are the functions and functions of Chinese medicine for windbreak? Let’s take a look at the functions and functions of Chinese medicine for windbreak.
Efficacy of Chinese medicine Fangfeng
Drug name: Fangfeng.
Alternative names: Mountain celery, white hair grass, copper rhizome, Huiyun, Huicao, Baizhi, Baijie, Baizhong, screen, Guanfangfeng, Sichuanfangfeng, Yunfangfeng, Dongfangfeng.
Chinese Pinyin: fang feng
English name: Divaricate Saposhnikovia Root, Root of Divaricate Saposhnikovia.
Efficacy: dispelling wind and relieving surface, relieving dampness and relieving pain, relieving spasm and relieving itching.
Indications: Exogenous wind and cold; headache and body aches; rheumatic arthralgia; joint pain; abdominal pain and diarrhea; intestinal wind and bleeding; tetanus; rubella and pruritus; initial onset of sores and ulcers.
Efficacy classification: external medicine; dispelling wind medicine
Ecological environment: grown in grasslands, hills and gravelly slopes.
Harvest and storage: Generally, it is harvested in the winter of the second year of field planting. If the land is improperly selected or poorly managed, it will take 3-4 years to harvest. After excavation, remove the residual stems, fibrous roots and soil. When they are 90% dry, they are tied into small bundles according to their thickness and length, and then dried in the sun or on a kang.
The effect of traditional Chinese medicine Fangfeng
① Antipyretic effect on rabbits with artificial fever. Oral administration of Fangfeng decoction or infusion has obvious antipyretic effect, and the decoction is more effective The dipping agent is good.
②Analgesic effect: Mice fed with 50% ethanol extract of Fangfeng (variety not identified) (ethanol is evaporated) can significantly increase the pain threshold (electrical stimulation of rat tail method), and subcutaneous injection is equally effective.
③The antibacterial effect of fresh Guan Fangfeng squeezed liquid was tested in vitro and it has certain antibacterial effect on Pseudomonas aeruginosa and Staphylococcus aureus.
Unidentified varieties of saposhnikovia decoction also have certain antibacterial effects on hemolytic Streptococcus and Shigella dysenteriae.
Guan Fangfeng Alcohol Extract is injected subcutaneously into rabbits and has no effect on blood sugar.
Analgesic effect
1. Effect on the writhing reaction of mice induced by acetic acid: 24 mice weighing 18-21g were equally divided into two groups and given Fangfeng water decoction respectively. (1ml contains 2g crude drug) 40g/kg and the same volume of water. After 1 hour, ip 0.5% acetic acid 0.2ml/20g, and observe the number of writhing reactions of mice within 20 minutes. The results showed that the number of writhing reactions of mice in the Fangfeng group was 11.4 to 1.8 times, which was significantly lower than the 19.2 to 2.4 times in the control group (P <0.05).
2. Effect on the pain threshold of mice: The hot plate method was used to measure the pain threshold. The condition is that the hot plate temperature is 55-0.5℃. Take female mice weighing 18-20g. After predicting the reaction latency, select 20 mice whose reaction latency does not exceed 30s. Divide them equally into two groups. Pouse Fangfeng water decoction equivalent to 40g/kg of crude drug and the same volume of water respectively, and measure the dose. The reaction latency of mice before and after taking the drug, the results are shown in Table 2. The reaction latency of the mice in the Fangfeng group was significantly prolonged at 60s and 90s after taking the drug (P<0.05).
3. Electrical stimulation of the rat tail method: The electrical stimulation of the rat tail method shows that the ethanol infusion of Fanggan has a certain analgesic effect on mice when given ig21.18g/kg and sc42.36g/kg. The analgesic rates after medication were 46.4% and 56.7% respectively, and the analgesic rates after 60 minutes were 39.O% and 53.3% respectively.
Sedative effect
1. Effect on subthreshold sleep dose of sodium pentobarbital: 40 mice weighing 20-28g were equally divided into two groups, and they were given Fengshui decoction. One hour after the dose of 40g/kg and the same volume of water, ip pentobarbital sodium 35mg/kg, record the number of animals falling asleep within 15 minutes, and the disappearance of the righting reflex for more than 1 minute is used as the falling asleep indicator. Results The number of mice falling asleep in the Fangfeng group (17, 85%) was significantly higher than that in the control group (17, 35%) (P<0.01).
2. Effect on the spontaneous activities of mice: 24 mice weighing 20-22g were divided equally into two groups, and the Fengfeng water decoction equivalent to 40g/kg and the same volume of water were poured for 50 minutes, and the records were recorded The number of mouse activities within 10 minutes.
The results were 226.3 to 35.9 in the antiseptic group and 326.7 to 27.7 in the control group. It can be seen that the spontaneous activity of the mice was significantly reduced by the antiseptic (P<0.01).
Anti-inflammatory effect
Twenty male mice weighing 24g-26g were equally divided into two groups. The dosage was the same as above. After 1 hour, 25ul of croton oil mixture was applied to the right ear to induce inflammation. The mice were sacrificed at 4 hours, weighed, and the degree of inflammatory response was observed. Results The degree of swelling in the Fangfeng group (13.9?0.9mg) was significantly lower than that in the control group (18.4?1.2mg) (P<0.05).
In vitro antibacterial test: The plate method was used to conduct an in vitro antibacterial test. The results showed that Fangfeng was effective against Staphylococcus aureus, beta-hemolytic Streptococcus, Diplococcus pneumoniae and two types of molds (Penicillium chrysogenum, P. Aspergillus (Aspergillus), etc. have antibacterial effects, but have no antibacterial effect on influenza bacilli, typhoid bacilli, flexneri and Shigella dysenteriae.
Anti-allergic effect
1. Effect on delayed-type hypersensitivity reaction caused by 2,4-dinitrochlorobenzene (DNCB):
Take Twenty male mice weighing 25-28g were evenly divided into two groups. The back skin was sensitized with 0.01ml of 5% DNCB acetone solution, and then sensitized again the next day. Administration began on the 5th day. The mice in the Fangfeng group were given Fangfeng 20g/day. kg, the control group took the same volume of water for 7 consecutive days. After the last administration, 0.02ml of 1% DNCB acetone was applied to the right ear, and the mice were killed 20 hours later. The left and right ear pieces (8 mm in diameter) were taken and weighed. The difference in tablet weight indicates the degree of delayed-type hypersensitivity reaction. The result was 2.90-0.45mg in the saposopix group, which was significantly lower than 4.88-0.78mg in the control group (P<0.05), indicating that sapsfoam has the effect of inhibiting delayed hypersensitivity reactions caused by DNCB.
2. Effect on allergic contraction of isolated tracheal and ileal smooth muscles of sensitized guinea pigs:
Take 10 guinea pigs weighing 250g-350g and inject 5% egg into the intraperitoneal cavity of each guinea pig. 1ml of protein and 0.4ml of each hind leg were injected for sensitization. Four weeks later, the allergic contraction test of isolated tracheal and ileal smooth muscle of guinea pigs was conducted. As a result, the tracheal contraction (2.8~0.5mm) was significantly lower than that in the control test (7.8~0.7mm). The results of the ileal contraction test showed that the contraction height of the 10-segment ileum was 31.8?4.3mm, which was significantly lower than the contraction height of the 10-segment ileum of the control group (42.4?5.2mm).
Effects on the phagocytic function of peritoneal macrophages in mice:
24 mice weighing 23-25g were divided into 2 groups and administered ig once a day for 4 consecutive days. day, after the last administration, ip 0.5ml of 5% chicken red blood cell solution at the same time and then sacrificed, and the phagocytosis percentage and phagocytic index of red blood cells were calculated.
Antipyretic effect
The rabbits were treated with triple vaccine (pertussis, diphtheria, tetanus vaccine) to create an animal fever model. Ip Guanfengfeng water decoction 2g/kg, with antipirin and normal saline as controls. Fengfeng decoction has obvious antipyretic effect within 1-2 hours.